The Polymerase Chain Reaction and Branching Processes
نویسنده
چکیده
We construct a mathematical model for the polymerase chain reaction and its mutations using the theory of branching processes. Under this model we study the number of mutations in a randomly chosen sequence after n PCR cycles. A method for estimating the mutation is proposed and the variance of this estimator is studied. We also study the distribution of the Hamming distance between two randomly chosen sequences and a method for estimating the mutation rate based on pairwise differences is proposed.
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ورودعنوان ژورنال:
- Journal of computational biology : a journal of computational molecular cell biology
دوره 2 1 شماره
صفحات -
تاریخ انتشار 1995